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KMID : 0380319910470000131
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Journal of Korean Research Institute for Better Living
1991 Volume.47 No. 0 p.131 ~ p.138
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The Effect of Piracetam on Memory and Acetylchline Level in Cerebral Cortex of Mice
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尹再順/Yun, Jae-Soon
申精姬/李容筍/劉永瓚/Shin, Jeung-Hee/Lee, Young-Soon/Yoo, Young-Chan
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Abstract
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The central cholinergic synapse is known to be closely connected with memory. Previously, piracetam has been reported to improve the intellectual ability. We used a scopolamine-induced amnesiac mouse to study the effects of piracetam on memory retrieval by passive avoidance learning test and on the acetylcholine level of cerebral cortex.
The amnesia was produced in mouse by the intraperitoneal injection(i.p.) of scopolamine at a dose of 1 ㎎/㎏ body weight(b.w.). Upon administration of piracetam to amnesiac mouse at doses of 100 and 200 ㎎/㎏ b.w., i.p., 30 min, prior to retrieval test, the significant improvement on memory impairment was observed by examination 24 hr after training. The level of acetylcholine in cerebral cortex of mouse was decreased by the scopolamine treatment, however, this decrease was attenuated by piracetam. These results suggest that the effect of piracetam on memory may be attributed to activation of cholinergic nerve.
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KEYWORD
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